NGAL and AKI (Acute Kidney Injury)

NGAL and AKI (Acute Kidney Injury)

A fast-responding biomarker for AKI, NGAL monomers are secreted in high levels into blood and urine upon injury of the kidney (within 2 hours or less).

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NGAL in Cancer Research

NGAL in Cancer Research

NGAL is expressed in a number of solid tumours, and is the subject of research into its potential as a prognostic and diagnostic biomarker in cancer.

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NGAL in Drug Development

NGAL in Drug Development

NGAL a sensitive and rapidly responding biomarker of acute kidney injury (AKI). This means that it is able to quickly detect nephrotoxicity caused by candidate compounds.

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NGAL in Inflammatory Disease Research

NGAL in Inflammatory Disease Research

NGAL levels are elevated in a number of inflammatory disease conditions, and the role of NGAL in their pathophysiology is of active interest.

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What is NGAL?

NGAL (neutrophil gelatinase-associated lipocalin or lipocalin-2) is a protein expressed by the LCN2 gene in humans and other mammals. Although it is expressed in healthy tissue it has attracted considerable interest due to it being upregulated in response to a variety of stresses and disease states.

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How NGAL Assays can Improve Drug Development

NGAL can detect acute kidney injury (AKI) within 2 hours of onset. This facilitates drug development by allowing potentially nephrotoxic compounds to be quickly excluded from the process.

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How NGAL Assays can Aid Research into Cancer and other Diseases

As NGAL has been implicated in the pathophysiology of a number of malignant and benign diseases, accurate determination of NGAL in affected tissues is important to elucidate the role of NGAL in disease, and its potential as a biomarker for various disease states.

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NGAL Products

  • NGAL Rapid ELISA
    CE IVD
  • Human NGAL ELISA
    for Research
  • Animal NGAL ELISAs
    for Research
  • NGAL-Monomer-Recombinant-Human-187x95NGAL (Monomer) Recombinant
  • Monoclonal Anti-NGAL
    antibodies