NGAL (neutrophil gelatinase-associated lipocalin or lipocalin-2) is a protein expressed by the LCN2 gene in humans and other mammals. Although it is expressed in healthy tissue it has attracted considerable interest due to it being upregulated in response to a variety of stresses and disease states.
NGAL can detect acute kidney injury (AKI) within 2 hours of onset. This facilitates drug development by allowing potentially nephrotoxic compounds to be quickly excluded from the process.
As NGAL has been implicated in the pathophysiology of a number of malignant and benign diseases, accurate determination of NGAL in affected tissues is important to elucidate the role of NGAL in disease, and its potential as a biomarker for various disease states.